Prevalencia global y factores asociados del hipotiroidismo congénito transitorio
DOI:
https://doi.org/10.31790/inspilip.v9i30.813Palabras clave:
Hipotiroidismo, Atención primaria de salud, Prevalencia, Diagnóstico precoz, EcuadorResumen
Introducción: La prevalencia de hipotiroidismo congénito transitorio puede variar geográficamente por las condiciones de cada sector. Identificar la frecuencia de los factores asociados en cada grupo permitirá implementar estrategias de salud pública adecuadas a la realidad de cada país para evitar tratamientos excesivos, preocupaciones familiares y otras consecuencias. Objetivo: Describir la prevalencia global y factores asociados del hipotiroidismo congénito transitorio. Método: La búsqueda avanzada se realizó en PubMed/Medline y BVS empleando operadores booleanos (AND, OR, NOT) y términos DeCS/MeSH obteniendo 480 resultados que fueron importados a Rayyan software 29 para eliminar duplicados manualmente y finalmente seleccionar 31 artículos que cumplieron con los criterios de elegibilidad. Resultados y Discusión: Se reportaron aproximadamente 12.394.251 participantes en los estudios elegidos de los cuales 9.540 padecían hipotiroidismo congénito y de estos 3.087 eran de tipo transitorio. El continente asiático presenta la mayor tasa de hipotiroidismo congénito transitorio seguido de América Latina. Conclusión: Los programas nacionales de tamizaje neonatal de cada país deben considerar los factores asociados para hipotiroidismo congénito transitorio actuales para implementar las nuevas estrategias de salud pública que permitirán controlar mejor esta condición.
Citas
1. Oron T, Lazar L, Ben-Yishai S, Tenenbaum A, Yackobovitch-Gavan M, Meyerovitch J, et al. Permanent vs Transient Congenital Hypothyroidism: Assessment of Predictive Variables. J Clin Endocrinol Metab. 1 de diciembre de 2018;103(12):4428-36.
2. Gunnerbeck A, Lundholm C, von Döbeln U, Zetterström RH, Almqvist C, Nordenström A. Neonatal screening for congenital hypothyroidism in Sweden 1980-2013: effects of lowering the thyroid-stimulating hormone threshold. Eur J Endocrinol. 1 de junio de 2023;188(6):536-46.
3. Lain S, Trumpff C, Grosse SD, Olivieri A, Van Vliet G. Are lower TSH cutoffs in neonatal screening for congenital hypothyroidism warranted? Eur J Endocrinol. noviembre de 2017;177(5):D1-12.
4. Lain SJ, Bentley JP, Wiley V, Roberts CL, Jack M, Wilcken B, et al. Association between borderline neonatal thyroid-stimulating hormone concentrations and educational and developmental outcomes: a population-based record-linkage study. Lancet Diabetes Endocrinol. septiembre de 2016;4(9):756-65.
5. Oren A, Wang MK, Brnjac L, Mahmud FH, Palmert MR. Mild neonatal hyperthyrotrophinaemia: 10-year experience suggests the condition is increasingly common but often transient. Clin Endocrinol (Oxf). 2013;79(6):832-7.
6. Mirabella G, Feig D, Astzalos E, Perlman K, Rovet JF. The effect of abnormal intrauterine thyroid hormone economies on infant cognitive abilities. J Pediatr Endocrinol Metab JPEM. febrero de 2000;13(2):191-4.
7. Gu X, Wang J, Ye J, Cheng X. [A cost-benefit evaluation of neonatal screening for phenylketonuria and congenital hypothyroidism]. Zhonghua Yu Fang Yi Xue Za Zhi. mayo de 2000;34(3):147-9.
8. Cassio A, Corbetta C, Antonozzi I, Calaciura F, Caruso U, Cesaretti G, et al. The Italian screening program for primary congenital hypothyroidism: Actions to improve screening, diagnosis, follow-up, and surveillance. J Endocrinol Invest. 1 de marzo de 2013;36(3):195-203.
9. Gmür S, Konrad D, Fingerhut R. Prevalence of Transient Hypothyroidism in Children Diagnosed with Congenital Hypothyroidism between 2000 and 2016. Int J Mol Sci. 1 de febrero de 2023;24(3):2817.
10. Cedillo-Balcázar, Jamil; Vásquez-Lapo, Doménica; Benítez-Paccha, M. Belén; Torres-Chamba, Angie; E. Moscoso-Chuchuca, Jorge. Prevalencia Global y Factores Asociados del Hipotiroidismo Congénito Transitorio [Internet]. figshare; 2023 [citado 27 de septiembre de 2023]. Disponible en: https://figshare.com/articles/dataset/Prevalencia_Global_y_Factores_Asociados_del_Hipotiroidismo_Cong_nito_Transitorio/24186348/1
11. Delshad H, Touhidi M, Abdollahi Z, Hedayati M, Salehi F, Azizi F. Inadequate iodine nutrition of pregnant women in an area of iodine sufficiency. J Endocrinol Invest. julio de 2016;39(7):755-62.
12. Gumes-Felix HM, Ramalho RJR, Melo EV, Matos DM, Menezes NV, Oliveira CRP, et al. Predictive factors for the diagnosis of permanent congenital hypothyroidism and its temporal changes in Sergipe, Brazil – A real-life retrospective study. Arch Endocrinol Metab. 2023;67(2):189-96.
13. Marr A, Yokubynas N, Tang K, Saleh D, Wherrett DK, Stein R, et al. Transient vs Permanent Congenital Hypothyroidism in Ontario, Canada: Predictive Factors and Scoring System. J Clin Endocrinol Metab. 2 de noviembre de 2021;107(3):638-48.
14. Habib A, Shojazadeh A, Molayemat M, Habib A, Jeddi M, Arabsolghar R, et al. Prevalence and predictive factors of transient and permanent congenital hypothyroidism in Fars province, Iran. BMC Pediatr. 5 de junio de 2021;21(1):264.
15. Caiulo S, Corbetta C, Di Frenna M, Medda E, De Angelis S, Rotondi D, et al. Newborn Screening for Congenital Hypothyroidism: the Benefit of Using Differential TSH Cutoffs in a 2-Screen Program. J Clin Endocrinol Metab. 1 de enero de 2021;106(1):e338-49.
16. Zhou J, Luo J, Lin J, Zeng Y, Qiu X, Zhu W, et al. Perinatal risk factors for congenital hypothyroidism. Medicine (Baltimore). 26 de junio de 2020;99(26):e20838.
17. Ford GA, Denniston S, Sesser D, Skeels MR, LaFranchi SH. Transient versus permanent congenital hypothyroidism after age 3 years in infants detected by the first vs. second newborn screening test in Oregon. Horm Res Paediatr. 2016;86(3):169-77.
18. Kara C, Günindi F, Can Yılmaz G, Aydın M. Transient Congenital Hypothyroidism in Turkey: An Analysis on Frequency and Natural Course. J Clin Res Pediatr Endocrinol. junio de 2016;8(2):170-9.
19. Dorreh F, Chaijan PY, Javaheri J, Zeinalzadeh AH. Epidemiology of Congenital Hypothyroidism in Markazi Province, Iran. J Clin Res Pediatr Endocrinol. junio de 2014;6(2):105-10.
20. The increased incidence of congenital hypothyroidism: fact or fancy? - Mitchell - 2011 - Clinical Endocrinology - Wiley Online Library [Internet]. [citado 23 de septiembre de 2023]. Disponible en: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2011.04128.x
21. A Study of the Etiology of Congenital Hypothyroidism in the Niigata Prefecture of Japan in Patients Born Between 1989 and 2005 and Evaluated at Ages 5–19 | Thyroid® [Internet]. [citado 23 de septiembre de 2023]. Disponible en: https://www.liebertpub.com/doi/full/10.1089/thy.2010.0005
22. SEASONAL VARIATION OF NEONATAL TRANSIENT HYPERTHYROTROPINEMIA IN TEHRAN PROVINCE, 1998–2005: Chronobiology International: Vol 27, No 9-10 [Internet]. [citado 23 de septiembre de 2023]. Disponible en: https://www.tandfonline.com/doi/full/10.3109/07420528.2010.516046?scroll=top&needAccess=true&role=tab
23. Permanent and transient congenital hypothyroidism in Isfahan–Iran - Mahin Hashemipour, Silva Hovsepian, Roya Kelishadi, Ramin Iranpour, Rezvane Hadian, Sassan Haghighi, Angineh Gharapetian, Mojtaba Talaei, Massoud Amini, 2009 [Internet]. [citado 23 de septiembre de 2023]. Disponible en: https://journals.sagepub.com/doi/10.1258/jms.2009.008090
24. Balzaretti M, Kozak A, Fernández Gianotti T, Alonso G, Jenik A, Fainstein Day P. Pesquisa de hipotiroidismo congénito: resultados de dieciocho años de trabajo ininterrumpido en el Hospital Italiano de Buenos Aires. Rev Hosp Ital B Aires 2004. 2008;57-62.
25. Aminzadeh M. Higher prevalence of permanent congenital hypothyroidism in the Southwest of Iran mostly caused by dyshormonogenesis: a five-year follow-up study. Arch Endocrinol Metab. 2018;62:602-8.
26. Congenital Hypothyroidism: Increased Incidence in Najran Province, Saudi Arabia | Journal of Tropical Pediatrics | Oxford Academic [Internet]. [citado 23 de septiembre de 2023]. Disponible en: https://academic.oup.com/tropej/article/42/6/348/1679280?login=false
27. Gunnerbeck A, Lundholm C, von Döbeln U, Zetterström RH, Almqvist C, Nordenström A. Neonatal screening for congenital hypothyroidism in Sweden 1980-2013: effects of lowering the thyroid-stimulating hormone threshold. Eur J Endocrinol. 1 de junio de 2023;188(6):536-46.
28. Anastasovska V, Pesevska M, Zdraveska N, Zafirova B, Jovcevska JM, Kocova M. Prevalence of congenital hypothyroidism in north macedonia: data from a newborn screening program conducted for twenty years. Turk J Pediatr. 2023;65(2):227.
29. Donbaloğlu Z, Çetinkaya S, Aycan Z, Küçükali GK, Şakar M, Savaş-Erdeve Ş. Evaluation of permanent and transient congenital hypothyroidism in cases referred from National Neonatal Screening Program. J Paediatr Child Health. 1 de agosto de 2022;58(8):1431-8.
30. Barry Y, Mandereau-Bruno L, Bonaldi C, Cheillan D, Coutant R, Léger J, et al. Prevalence and Determinants of Transient Congenital Hypothyroidism in Children With Eutopic Gland in France: A Retrospective Cohort Study. J Clin Endocrinol Metab. 1 de abril de 2022;107(4):e1501-9.
31. Matejek N, Tittel SR, Haberland H, Rohrer T, Busemann EM, Jorch N, et al. Predictors of transient congenital primary hypothyroidism: data from the German registry for congenital hypothyroidism (AQUAPE «HypoDok»). Eur J Pediatr. agosto de 2021;180(8):2401-8.
32. Mehran L, Azizi F, Mousapour P, Cheraghi L, Yarahmadi S, Amirshekari G, et al. Development of a risk prediction model for early discrimination between permanent and transient congenital hypothyroidism. Endocrine. 1 de agosto de 2021;73(2):374-83.
33. Medda E, Vigone MC, Cassio A, Calaciura F, Costa P, Weber G, et al. Neonatal Screening for Congenital Hypothyroidism: What Can We Learn From Discordant Twins? J Clin Endocrinol Metab. 1 de diciembre de 2019;104(12):5765-79.
34. Jaruratanasirikul S, Janjindamai W, Sriplung H. Congenital hypothyroidism in preterm infants: a 3- to 8-year longitudinal study in southern Thailand. J Pediatr Endocrinol Metab. 1 de noviembre de 2019;32(11):1275-82.
35. McGrath N, Hawkes CP, Mayne P, Murphy NP. Permanent Decompensated Congenital Hypothyroidism in Newborns with Whole-Blood Thyroid-Stimulating Hormone Concentrations between 8 and 10 mU/L: The Case for Lowering the Threshold. Horm Res Paediatr. 25 de mayo de 2018;89(4):265-70.
36. Matos DM, Ramalho RJR, Carvalho BM, Almeida MACT, Passos LFD, Vasconcelos TTS, et al. Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil. Arch Endocrinol Metab. 25 de agosto de 2016;60:450-6.
37. Mitrovic K, Vukovic R, Milenkovic T, Todorovic S, Radivojcevic J, Zdravkovic D. Changes in the incidence and etiology of congenital hypothyroidism detected during 30 years of a screening program in central Serbia. Eur J Pediatr. 1 de febrero de 2016;175(2):253-9.
38. Olivieri A, Corbetta C, Weber G, Vigone MC, Fazzini C, Medda E, et al. Congenital hypothyroidism due to defects of thyroid development and mild increase of TSH at screening: data from the Italian National Registry of infants with congenital hypothyroidism. J Clin Endocrinol Metab. abril de 2013;98(4):1403-8.
39. Mitchell ML, Hsu HW, Sahai I, Massachusetts Pediatric Endocrine Work Group. The increased incidence of congenital hypothyroidism: fact or fancy? Clin Endocrinol (Oxf). diciembre de 2011;75(6):806-10.
40. Nagasaki K, Asami T, Ogawa Y, Kikuchi T, Uchiyama M. A Study of the Etiology of Congenital Hypothyroidism in the Niigata Prefecture of Japan in Patients Born Between 1989 and 2005 and Evaluated at Ages 5–19. Thyroid®. abril de 2011;21(4):361-5.
41. Zung A, Tenenbaum-Rakover Y, Barkan S, Hanukoglu A, Hershkovitz E, Pinhas-Hamiel O, et al. Neonatal hyperthyrotropinemia: population characteristics, diagnosis, management and outcome after cessation of therapy. Clin Endocrinol (Oxf). 2010;72(2):264-71.
42. Foo A, Leslie H, Carson DJ. Confirming congenital hypothyroidism identified from neonatal screening. Ulster Med J. mayo de 2002;71(1):38-41.
43. Ray M, Muir T, Murray G, Kennedy R, Girdwood R, Donaldson M. Audit of screening programme for congenital hypothyroidism in Scotland 1979-93. Arch Dis Child. mayo de 1997;76(5):411-5.
44. Congenital Hypothyroidism: Increased Incidence in Najran Province, Saudi Arabia | Journal of Tropical Pediatrics | Oxford Academic [Internet]. [citado 23 de septiembre de 2023]. Disponible en: https://academic.oup.com/tropej/article/42/6/348/1679280?login=false
45. Pearce MS, McNally RJQ, Day J, Korada SM, Turner S, Cheetham TD. Space–time clustering of elevated thyroid stimulating hormone levels. Eur J Epidemiol. 1 de mayo de 2011;26(5):405-11.
46. McNally RJQ, Jones JH, Shaikh MG, Donaldson MDC, Blakey K, Cheetham TD. Congenital Hypothyroidism: Space–Time Clustering of Thyroid Dysgenesis Indicates a Role for Environmental Factors in Disease Etiology. Thyroid. 1 de junio de 2021;31(6):876-83.
47. Steinmaus CM. Perchlorate in Water Supplies: Sources, Exposures, and Health Effects. Curr Environ Health Rep. junio de 2016;3(2):136-43.
48. Harari-Kremer R, Calderon-Margalit R, Korevaar TIM, Nevo D, Broday D, Kloog I, et al. Associations Between Prenatal Exposure to Air Pollution and Congenital Hypothyroidism. Am J Epidemiol. 1 de diciembre de 2021;190(12):2630-8.
49. Simsek E, Karabay M, Kocabay K. Neonatal screening for congenital hypothyroidism in West Black Sea area, Turkey. Int J Clin Pract. marzo de 2005;59(3):336-41.
50. Hinton CF, Harris KB, Borgfeld L, Drummond-Borg M, Eaton R, Lorey F, et al. Trends in Incidence Rates of Congenital Hypothyroidism Related to Select Demographic Factors: Data From the United States, California, Massachusetts, New York, and Texas. Pediatrics. 1 de mayo de 2010;125(Supplement_2):S37-47.
51. Shaghaghian S, Rahimi N, Mousavi-Roknabadi RS, Azadian F, Nazemzadegan B, Ghasempour H, et al. Appropriateness of Congenital Hypothyroidism Screening Program in Fars Province, Iran: A Retrospective Study from 2005 to 2015. Iran J Med Sci. mayo de 2019;44(3):245-50.
52. Acquired hypothyroidism in childhood and adolescence - UpToDate [Internet]. [citado 4 de octubre de 2023]. Disponible en: https://www.uptodate.com/contents/acquired-hypothyroidism-in-childhood-and-adolescence?source=Out%20of%20date%20-%20zh-Hans
53. Rastogi MV, LaFranchi SH. Congenital hypothyroidism. Orphanet J Rare Dis. 10 de junio de 2010;5(1):17.
54. Mutlu M, Karagüzel G, Alıyazicioğlu Y, Eyüpoğlu I, Okten A, Aslan Y. Reference intervals for thyrotropin and thyroid hormones and ultrasonographic thyroid volume during the neonatal period. J Matern-Fetal Neonatal Med Off J Eur Assoc Perinat Med Fed Asia Ocean Perinat Soc Int Soc Perinat Obstet. febrero de 2012;25(2):120-4.
55. Léger J, Olivieri A, Donaldson M, Torresani T, Krude H, van Vliet G, et al. European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism. J Clin Endocrinol Metab. febrero de 2014;99(2):363-84.
56. Bezen D, Dilek E, Torun N, Tütüncüler F. Etiological evaluation of primary congenital hypothyroidism cases. Turk Arch Pediatr Pediatri Arş. 1 de junio de 2017;52(2):85-91.
57. Cherella CE, Wassner AJ. Update on congenital hypothyroidism. Curr Opin Endocrinol Diabetes Obes. febrero de 2020;27(1):63-9.
58. Prevalence and Determinants of Transient Congenital Hypothyroidism in Children With Eutopic Gland in France: A Retrospective Cohort Study | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic [Internet]. [citado 23 de septiembre de 2023]. Disponible en: https://academic.oup.com/jcem/article/107/4/e1501/6444906?login=false
59. Donbaloğlu Z, Savaş-Erdeve Ş, Çetinkaya S, Aycan Z. Cases Referred from the Turkish National Screening Program: Frequency of Congenital Hypothyroidism and Etiological Distribution. J Clin Res Pediatr Endocrinol. septiembre de 2019;11(3):240-6.
60. Srinivasan R, Harigopal S, Turner S, Cheetham T. Permanent and transient congenital hypothyroidism in preterm infants. Acta Paediatr Oslo Nor 1992. abril de 2012;101(4):e179-182.
61. Lawrence SE, von Oettingen JE, Deladoëy J. Chapter 43 - Fetal and Postnatal Disorders of Thyroid Function. En: Kovacs CS, Deal CL, editores. Maternal-Fetal and Neonatal Endocrinology [Internet]. Academic Press; 2020 [citado 28 de septiembre de 2023]. p. 735-54. Disponible en: https://www.sciencedirect.com/science/article/pii/B9780128148235000441
62. Ordookhani A, Pearce EN, Mirmiran P, Azizi F, Braverman LE. Transient congenital hypothyroidism in an iodine-replete area is not related to parental consanguinity, mode of delivery, goitrogens, iodine exposure, or thyrotropin receptor autoantibodies. J Endocrinol Invest. enero de 2008;31(1):29-34.
63. Dechant MJ, Werf-Grohmann N van der, Neumann E, Spiekerkoetter U, Stiller B, Grohmann J. Thyroidal response following iodine excess for cardiac catheterisation and intervention in early infancy. Int J Cardiol. 15 de noviembre de 2016;223:1014-8.
64. Sun D, Codling K, Chang S, Zhang S, Shen H, Su X, et al. Eliminating Iodine Deficiency in China: Achievements, Challenges and Global Implications. Nutrients. abril de 2017;9(4):361.
65. Livett T, LaFranchi S. Imaging in congenital hypothyroidism. Curr Opin Pediatr. agosto de 2019;31(4):555.
66. Lm M, Et K, Cr N, Gm M, Pk M, Ml N, et al. Congenital hypothyroidism: recommendations of the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism. Arq Bras Endocrinol Metabol [Internet]. abril de 2013 [citado 4 de octubre de 2023];57(3). Disponible en: https://pubmed.ncbi.nlm.nih.gov/23681264/
67. Tuli G, Munarin J, Topalli K, Pavanello E, de Sanctis L. Neonatal Screening for Congenital Hypothyroidism in Preterm Infants: Is a Targeted Strategy Required? Thyroid®. abril de 2023;33(4):440-8.
68. Zhou J, Luo J, Lin J, Zeng Y, Qiu X, Zhu W, et al. Perinatal risk factors for congenital hypothyroidism: A retrospective cohort study performed at a tertiary hospital in China. Medicine (Baltimore) [Internet]. 6 de junio de 2020 [citado 23 de septiembre de 2023];99(26). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328952/
69. Skordis N, Toumba M, Savva SC, Erakleous E, Topouzi M, Vogazianos M, et al. High prevalence of congenital hypothyroidism in the Greek Cypriot population: results of the neonatal screening program 1990-2000. J Pediatr Endocrinol Metab JPEM. mayo de 2005;18(5):453-61.
70. Salerno M, Militerni R, Bravaccio C, Micillo M, Capalbo D, Di MS, et al. Effect of different starting doses of levothyroxine on growth and intellectual outcome at four years of age in congenital hypothyroidism. Thyroid Off J Am Thyroid Assoc. enero de 2002;12(1):45-52.
71. Selva KA, Mandel SH, Rien L, Sesser D, Miyahira R, Skeels M, et al. Initial treatment dose of L-thyroxine in congenital hypothyroidism. J Pediatr. diciembre de 2002;141(6):786-92.
72. Goldis M, Waldman L, Marginean O, Rosenberg HK, Rapaport R. Thyroid Imaging in Infants. Endocrinol Metab Clin North Am. junio de 2016;45(2):255-66.
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