Tormenta tiroidea, una emergencia endocrina. Directrices actualizadas de su manejo
DOI:
https://doi.org/10.31790/inspilip.v7i22.423Palabras clave:
Tirotoxicosis, Crisis tiroidea, Terapia, Antitiroideos [DeCS]Resumen
La tormenta tiroidea es una emergencia endocrino metabólica potencialmente mortal, por lo que, contar con un resumen de la mejor evidencia actualizada sobre su tratamiento, resulta de gran importancia. Con el propósito de describir las directrices actuales de manejo de la TT se realizó esta revisión sistemática flexible, a partir de guías, documentos de consenso y artículos de revisión. Se desarrolló una búsqueda basada en términos Mesh, con la que se seleccionaron 15 publicaciones, desde 2015 hasta la actualidad. La evidencia consultada indica que el manejo de la tormenta tiroidea es multimodal. Implica medidas de soporte: como ingreso en UCI, Identificar y tratar factores precipitantes, oxígeno 5-6L/min, control agresivo de la temperatura, vigilancia del equilibrio hidroelectrolítico y ácido base, hidratación (SSF y Dextrosa 5 % - 10 %), sedación, vitaminoterapia, y protección gástrica. Las medidas específicas incluyen el uso de Propiltiuoracilo (500-1000 mg dosis de carga), después, 250 mg cada 4 horas, Metimazol (60-80 mg/día), Propranolol (60-80 mg cada 4 horas), Iodine (KI) 5 gotas vía oral cada 6 horas e Hicrocortisona (300 mg de carga, después, 100 mg cada 8 horas). Con esta revisión se evidenció que, al ser la tormenta tiroidea es una emergencia potencialmente mortal, amerita una actualización permanente en el abordaje terapéutico, con revisión y divulgación continua de las recomendaciones actuales de tratamiento, como una herramienta de consulta rápida que beneficie a los profesionales médicos y a sus pacientes.
Citas
Spencer L, Bubner T, Bain E, Middleton P. Screening and subsequent management for thyroid dysfunction pre-pregnancy and during pregnancy for improving maternal and infant health. Cochrane Database Syst Rev [Internet]. 2015 Sep 21;2015(9):1–50. Available from: http://doi.wiley.com/10.1002/14651858.CD011263.pub2.
Lissauer D, Cheshire J, Dunlop C, Taki F, Wilson A, Smith J, et al. Development of the FAST‐M maternal sepsis bundle for use in low‐resource settings: a modified Delphi process. BJOG An Int J Obstet Gynaecol [Internet]. 2020;127(3):416–23. Available from: /pmc/articles/PMC7384197/.
Lahey F. The Crisis of Exophthalmic Goiter. N Engl J Med [Internet]. 1928;199(6):255–7. Available from: http://www.nejm.org/doi/abs/10.1056/NEJM192808091990601.
Bourcier S, Coutrot M, Kimmoun A, Sonneville R, de Montmollin E, Persichini R, et al. Thyroid Storm in the ICU: A Retrospective Multicenter Study. Crit Care Med [Internet]. 2020;48(1):83–90. Available from: https://journals.lww.com/ccmjournal/Fulltext/2020/01000/Thyroid_Storm_in_the_ICU__A_Retrospective.11.aspx.
Galindo R, Hurtado C, Pasquel F, García Tome R, Peng L, Umpierrez G. National Trends in Incidence, Mortality, and Clinical Outcomes of Patients Hospitalized for Thyrotoxicosis With and Without Thyroid Storm in the United States, 2004–2013. Thyroid [Internet]. 2019 Jan;29(1):36–43. Available from: https://www.liebertpub.com/doi/10.1089/thy.2018.0275.
Raza M, Jain A, Mumtaz M, Mehmood T. Thyroid Storm in a Patient on Chronic Amiodarone Treatment. Cureus [Internet]. 2022;14(4):56–74. Available from: https://pubmed.ncbi.nlm.nih.gov/35586348/.
Brouwers M, Kerkvliet K, Spithoff K. The AGREE Reporting Checklist: a tool to improve reporting of clinical practice guidelines. BMJ [Internet]. 2016 Mar 8 [cited 2023 Jan 12];352(2):11–25. Available from: https://www.bmj.com/lookup/doi/10.1136/bmj.i1152.
Brouwers M, Kho M, Browman G, Burgers J, Cluzeau F, Feder G, et al. The Global Rating Scale complements the AGREE II in advancing the quality of practice guidelines. J Clin Epidemiol [Internet]. 2012 May;65(5):526–34. Available from: https://linkinghub.elsevier.com/retrieve/pii/S089543561100326X.
Satoh T, Isozaki O, Suzuki A, Wakino S, Iburi T, Tsuboi K, et al. 2016 Guidelines for the management of thyroid storm from The Japan Thyroid Association and Japan Endocrine Society (First edition). Endocr J [Internet]. 2016;63(12):1025–64. Available from: https://www.jstage.jst.go.jp/article/endocrj/63/12/63_EJ16-0336/_article.
Ross D, Burch H, Cooper D, Greenlee C, Laurberg P, Maia A, et al. 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid [Internet]. 2016;26(10):1343–421. Available from: https://www.liebertpub.com/doi/10.1089/thy.2016.0229.
Dorris K. American Thyroid Association Task Force Updates Treatment Guidelines for Hyperthyroidism. Clin Thyroidol [Internet]. 2016 [cited 2023 Jan 12];9(2):56–9. Available from: https://www.thyroid.org/wp-content/uploads/publications/ctfp/volume9/issue11/ct_public_v911_3_7.pdf.
Kahaly G, Bartalena L, Hegedüs L, Leenhardt L, Poppe K, Pearce S. 2018 European Thyroid Association Guideline for the Management of Graves’ Hyperthyroidism. Eur Thyroid J [Internet]. 2018;7(4):167–86. Available from: https://etj.bioscientifica.com/view/journals/etj/7/4/ETJ490384.xml.
Cabañas M, Carrera B, Pérez L, Troyano M. Protocolo diagnóstico y tratamiento de la tormenta tiroidea. Med - Programa Form Médica Contin Acreditado [Internet]. 2020;13(13):742–6. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0304541220301736.
Flores A, Castillo Y. Protocolo de diagnóstico y tratamiento de la tormenta tiroidea. Hormonas [Internet]. 2021;12(1):3–14. Available from: http://sodenn.com/wp-content/uploads/2021/06/Suplemento-1.-Revista-Hormonas-web.pdf.
Akamizu T. Thyroid Storm: A Japanese Perspective. Thyroid [Internet]. 2018;28(1):32–40. Available from: https://www.liebertpub.com/doi/10.1089/thy.2017.0243.
Chiha M, Samarasinghe S, Kabaker A. Thyroid Storm. J Intensive Care Med [Internet]. 2015 Mar 5;30(3):131–40. Available from: http://journals.sagepub.com/doi/10.1177/0885066613498053.
Idrose A. Acute and emergency care for thyrotoxicosis and thyroid storm. Acute Med Surg [Internet]. 2015;2(3):147–57. Available from: https://onlinelibrary.wiley.com/doi/10.1002/ams2.104.
Isozaki O, Satoh T, Wakino S, Suzuki A, Iburi T, Tsuboi K, et al. Treatment and management of thyroid storm: analysis of the nationwide surveys. Clin Endocrinol (Oxf) [Internet]. 2016;84(6):912–8. Available from: https://onlinelibrary.wiley.com/doi/10.1111/cen.12949.
Hernández R. Algunos elementos de interés acerca del diagnóstico y tratamiento de la tormenta tirotóxica. Rev Cuba Endocrinol [Internet]. 2022;33(1):24–32. Available from: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-29532022000100007.
Gutiérres J, Olaya S, Vallejo S, Bustamante V, Petrmina J. Consideraciones para el manejo de los pacientes críticos con enfermedad tiroidea. Rev Med Inst Mex Seguro Soc [Internet]. 2020;58(6):719–27. Available from: https://www.redalyc.org/journal/4577/457769357011/457769357011.pdf.
Carroll P V. Thyroid Emergency: Thyroid Storm and Myxoedema Coma. Adv Pract Endocrinol Nurs [Internet]. 2019 Jan 1 [cited 2023 Jan 12];1207–15. Available from: https://link.springer.com/chapter/10.1007/978-3-319-99817-6_63.
Jacobi J. Management of Endocrine Emergencies in the ICU. J Pharm Pract [Internet]. 2019 Jun 10;32(3):314–26. Available from: http://journals.sagepub.com/doi/10.1177/0897190019834771.
Ylli D, Klubo-Gwiezdzinska J, Wartofsky L. Thyroid emergencies. Polish Arch Intern Med [Internet]. 2019 Jun 25;129(7):526–34. Available from: https://www.mp.pl/paim/issue/article/14876.
Ishii M. Endocrine Emergencies With Neurologic Manifestations. Contin Lifelong Learn Neurol [Internet]. 2017 Jun;23(3):778–801. Available from: http://journals.lww.com/00132979-201706000-00013.
Subekti I, Pramono LA. Current Diagnosis and Management of Graves’ Disease. Acta Med Indones [Internet]. 2018 Apr;50(2):177–82. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29950539.
Bellamkonda A, Mustafa F, Chowdhury T, Gobena TM, Bellamkonda R. A Case Report and Literature Review of Thyroid Storm Precipitated by COVID-19 Infection: A Crucial Pointer for Early Suspicion. Cureus [Internet]. 2023 Feb 20;15(2):35–48. Available from: https://www.cureus.com/articles/139454-a-case-report-and-literature-review-of-thyroid-storm-precipitated-by-covid-19-infection-a-crucial-pointer-for-early-suspicion.
Farooqi S, Raj S, Koyfman A, Long B. High risk and low prevalence diseases: Thyroid storm. Am J Emerg Med [Internet]. 2023 Jul;69(2):127–35. Available from: https://linkinghub.elsevier.com/retrieve/pii/S073567572300150X.
Lee S, Modzelewski K, Law A, Walkey A, Pearce E, Bosch N. Comparison of Propylthiouracil vs Methimazole for Thyroid Storm in Critically Ill Patients. JAMA Netw Open [Internet]. 2023 Apr 17;6(4):238–51. Available from: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2803923.
Senda A, Endo A, Tachimori H, Fushimi K, Otomo Y. Early administration of glucocorticoid for thyroid storm: analysis of a national administrative database. Crit Care [Internet]. 2020 Dec 29;24(1):470. Available from: https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03188-8.
Tizianel I, Sabbadin C, Censi S, Clausi C, Colpo A, Leahu AI, et al. Therapeutic Plasma Exchange for the Treatment of Hyperthyroidism: Approach to the Patient with Thyrotoxicosis or Antithyroid-Drugs Induced Agranulocytosis. J Pers Med [Internet]. 2023 Mar 13;13(3):517. Available from: https://www.mdpi.com/2075-4426/13/3/517.
Publicado
Cómo citar
Número
Sección
Licencia

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.















